An unusually large myofibroblastoma in a male breast: a case report
IntroductionMyofibroblastoma of the breast is a rare benign stromal tumour seen predominantly in men. The gross appearance is that of a well-circumscribed nodule, characteristically small, seldom exceeding 3cm.
We present a case of an unusually large myofibroblastoma, which mimicked a malignant breast tumour.Case presentationA 65-year-old man presented with a rapid enlargement of the right breast over 6 weeks. Examination revealed a firm 15cm hemispherical lump occupying the whole of the right breast with peau d'orange appearance of the overlying skin and distortion of the nipple.
The clinical and radiological features suggested the possibility of sarcoma of the breast. However, a guided Tru-Cut biopsy was inconclusive.
A mastectomy was performed to remove the tumour, which weighed more than 2kg. Histopathology and immunocytochemistry revealed a mixed classical and collagenised type of myofibroblastoma.
The patient is well with no evidence of recurrence 5 years after the mastectomy.
Conclusion: This unexpected presentation of an unusually large myofibroblastoma in a male breast is the largest reported to date.
Myofibroblastomas can mimic malignant neoplasms and the clinical significance of this entity lies primarily in its recognition as a distinctive benign neoplasm.
Author: Ams Abeysekara, HP Priyantha Siriwardana, Kf Abbas, Peter Tanner and Akin A Ojo
Credits/Source: Journal of Medical Case Reports 2008, 2:157
Published on: 2008-05-14
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