Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions
Nm23 protein is a metastasis suppressor protein, expressed in all tissues. Reduced Nm23 expression is related to a high incidence of lymph node and distant metastasis and poor prognosis in patients with cancers.
The present study was done to analyze the expression of Nm23 using immunohistochemistry in non-neoplastic and neoplastic breast lesions.
Methods: Sections from 93 samples were studied and classified into non-proliferative breast lesion (13), fibrodenoma (7), proliferative breast lesion (13), carcinoma in situ (20), invasive carcinoma (23) and metastatic deposits in lymph nodes (17).
Results: Nm23 expression in these groups showed a progressive down regulation with increasing neoplastic transformation.
On comparing the various groups, nm23 expression was significantly different between the various subgroups with greatest expression in non-proliferative lesions and least in metastatic deposits (p<.05).
Conclusions: It is concluded that the modulation of nm23 in a spectrum of breast lesions can be indicative of metastatic phenotype and help to predict the aggressiveness of disease.
Author: Amanjit Bal, Kusum Joshi, Rajesh Logasundaram, Bd Radotra and Rajinder Singh
Credits/Source: Diagnostic Pathology 2008, 3:23
Published on: 2008-05-30
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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