Possible additional value of 18FDG-PET in managing pancreas intraductal papillary mucinous neoplasms. Preliminary results.
Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patients with Intraductal Papillary Mucinous Neoplasm (IPMN) studied both with 18FDG-PET and magnetic resonance cholangiopancreatography (MRCP).
A focal hypermetabolism was documented in 2 patients (the standardized uptake value in the neoplastic foci was 6.7 and 9), while absence of FDG uptake in the neoplasm area was recorded in the remaining 5 cases. Mean follow-up was 27 months (range 21-34).
The final judgement was benign IPMN in 5 cases and malignant IPMN in 2. PET scan always correctly predicted the presence or absence of malignancy, while MRCP failed to detect malignancy in 3/7 cases.
In conclusion, this preliminary experience suggests that 18FDG-PET may prove useful for malignancy detection in IPMN, improving differential diagnosis with benign intraductal papillary growth by functional data.
Author: Gian Luca Baiocchi, Nazario Portolani, Francesco Bertagna, Federico Gheza, Claudio Pizzocaro, Raffaele Giubbini and Stefano M. Giulini
Credits/Source: Journal of Experimental &Clinical Cancer Research 2008, 27:10
Published on: 2008-06-10
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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