Primary biliary cirrhosis with a normal alkaline phosphatase: a case report


A 78 year-old lady presented with abdominal swelling and fatigue. She was anaemic with mild hypoalbuminaemia, and had a normal alkaline phosphatase.

Computed tomography showed hepatosplenomegaly and mild ascites. Anti mitochondrial antibodies were strongly positive, as were anti nuclear antibodies, and the gamma glutamyl-transferase was shown to be elevated.

A diagnosis of primary biliary cirrhosis was made. A brief discussion of treatment of primary biliary cirrhosis follows.

The case is notable for the fact that primary biliary cirrhosis can manifest clinically without an elevation in alkaline phosphatase - normally the hallmark of the disease.

Author: Joshua M Brostoff, Sukaina Rashid and Daniel McCrea
Credits/Source: Cases Journal 2008, 1:33



Published on: 2008-07-14

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