Biphasic anaphylactic reaction to blue dye during sentinel lymph node biopsy

Lymphazurin 1% blue dye can cause a severe anaphylactic reaction in approximately 1-3% of patients. Case presentationWe describe a case of intraoperative anaphylaxis resulting from Lymphazurin 1% blue dye.

A 48-year old woman undergoing a mastectomy with sentinel lymph node biopsy experienced a biphasic anaphylactic reaction with two episodes of hypotension at 15 minutes and 2 hours, respectively, after injection of the blue dye. The late phase was initially refractory to epinephrine.

Conclusions: Early recognition, aggressive hemodynamic management, and prolonged monitoring are indicated in these patients to watch for a potential second phase anaphylactic reaction.

Author: Margaret I Liang and William E Carson
Credits/Source: World Journal of Surgical Oncology 2008, 6:79

Published on: 2008-07-27

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