The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma - report of a case

With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly. Case presentationThis paper describes a fast growing adenocarcinoma (NOS), originating in the minor salivary glands of the left buccal mucosa with a rapid onset of multiple local and distant metastases.

A simultaneous adenocarcinoma of the lung was excluded as primary by negative immunohistochemical analysis for the thyroid transcriptionfactor-1 protein (TTF-1).

Conclusion: A rare case of an adenocarcinoma (NOS) of the minor salivary glands with a rapid development and an unfavourable clinical course is reported.

It shows that additional immunohistochemical analysis can decisively contribute to determine the site of the primary tumour in cases with unknown primary.

Author: Tobias Ettl, Johannes Kleinheinz, Ravi Mehrotra, Stephan Schwarz, Torsten EUGEN Reichert and Oliver Driemel
Credits/Source: Head &Face Medicine 2008, 4:16

Published on: 2008-07-30

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