Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention.
The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes.
Methods: Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D3 per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D3 <50nmol/L), insulin resistant (HOMA-IR>1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia.
Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months.DiscussionThis randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered clinical trial - Registration No.
ACTRN12607000642482
Author: Pamela R von Hurst, Welma Stonehouse, Christophe Matthys, Cathryn Conlon, Marlena C Kruger and Jane Coad
Credits/Source: BMC Public Health 2008, 8:267
Published on: 2008-07-31
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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