Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
Prior studies using creatinine-based estimated glomerular filtration rate (eGFR) have found limited associations between kidney function and markers of inflammation. Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort.
Methods: The Multi-Ethnic Study of Atherosclerosis consists of 6,814 participants of white, African-American, Hispanic, and Chinese descent, enrolled from 2000-2002 from six U.S.
communities. Measurements at the enrollment visit included serum creatinine, cystatin C, and six inflammatory and procoagulant biomarkers.
Creatinine-based eGFR was estimated using the four-variable Modification of Diet in Renal Disease equation, and chronic kidney disease was defined by an eGFR <60 mL/min/1.73m2.
Results: Adjusted partial correlations between cystatin C and all biomarkers were statistically significant: C-reactive protein (r=0.08), interleukin-6 (r=0.16), tumor necrosis factor-alpha soluble receptor 1 (TNF-alphaR1; r=0.75), intercellular adhesion molecule-1 (r=0.21), fibrinogen (r=0.14), and factor VIII (r=0.11; two-sided p<0.01 for all). In participants without chronic kidney disease, higher creatinine-based eGFR was associated only with higher TNF-alphaR1 levels.
Conclusions: In a cohort characterized by ethnic diversity, cystatin C was directly associated with multiple procoagulant and inflammatory markers. Creatinine-based eGFR had similar associations with these biomarkers among subjects with chronic kidney disease.
Author: Christopher Keller, Ronit Katz, Mary Cushman, Linda F Fried and Michael Shlipak
Credits/Source: BMC Nephrology 2008, 9:9
Published on: 2008-08-05
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