Chorioallantoic placentation in Galea spixii (Rodentia, Caviomorpha, Caviidae)
To determine the variation of characters in close relatives it is essential to optimize the pool of potential animal models for human placentation. Placentas of guinea pig-related rodents are appropriate in this context because of their striking similarities to those of humans.
Methods: In this study we firstly analyzed the chorioallantoic placentation in the prea, Galea spixii, as one of the guinea pig's closest relatives. The material covers an ontogenetic sequence from initial pregnancy shortly after implantation to term.
The placentas were investigated by means of histology, immunohistochemistry, proliferation activity and electron microscopy.
Results: Placentation in Galea reveals major parallels to the guinea pig and other caviomorphs with respect to the regionalization of the placenta, the associated growing processes, as well as trophoblast invasion.
In contrast to the guinea pig however, the subplacenta as the center of origin for trophoblast invasiontemporarily is supplied in parallel by the maternal and fetal blood systems.
Conclusions: The similarity in invasion and expanding processes indicates that Galea may serve as an additional animal model that is much smaller than the guinea pig and where the subplacenta partly has access to both maternal and fetal blood systems.
Author: Moacir F Oliveira, Andrea Mess, Carlos E Ambrosio, Carlos AG Dantas, Phelipe O Favaron and Maria A Miglino
Credits/Source: Reproductive Biology and Endocrinology 2008, 6:39
Published on: 2008-09-04
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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