S100A4 overexpression proves to be independent marker for breast cancer progression.
Background, Breast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor.
In fact the function of the S100A4 protein and its role in metastasis is unclear at present. The purpose of the study was to determine the expression of S100A4 protein in the invasion status and metastatic potential of breast cancer by using tissue microarray and to determine its role in breast cancer based on the expression of S100A4 gene product.Method, S100A4 protein expression was examined by immunohistochemistry (IHC) using commercially available tissue microarray containing malignant and normal breast tissues from 216 patients.
Results, negative staining for S100A4 in all normal breast tissues, a similar percentage of cases showed positive staining for S100A4 in Infiltrating ductal carcinoma (IDC) node negative (45.1%) and Infiltrating lobular carcinoma (ILC) node negative (48.8%), Positive expression of S100A4 protein was observed only in 13.2 % of cases of IDC node positive while positive expression of S100A4 protein was observed in 30.4 % of its matched lymph node metastasis. Conclusions, S100A4 protein expression appears widely expressed in early and advanced breast cancer stages comparing with normal breast.
Our study suggests S100A4 may play a role in breast cancer progression also S100A4 may prove to be an independent marker of breast cancer which appears to be down regulated in more advanced stages of breast cancer.
Author: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan
Credits/Source: Cancer Cell International 2008, 8:12
Published on: 2008-09-05
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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