Sevoflurane requirement during elective ankle day surgery: the effects of etirocoxib premedication, a prospective randomised study.
Anti-inflammatory drugs, NSAIDs, have become an important part of the pain management in day surgery. The aim of the present study was to evaluate the effect of Coxib premedication on the intra-operative anaesthetic requirements in patients undergoing elective ankle surgery in general anaesthesia.
Type of study: Prospective, randomized study of the intra-operative anaesthetic effects of etoricoxib premedication.
Methods: The intra-operative requirement of sevoflurane was studied in forty-four ASA 1-2 patients undergoing elective ankle day surgical in general anaesthesia.
Primary study endpoint was end-tidal sevoflurane concentration to maintain Cerebral State Index of 40 - 50 intra-operatively.
Results: All anaesthesia and surgery was uneventful, no complications or adverse events were noticed.
The mean end-tidal sevoflurane concentration intra-operatively was 1.25 (SD 0.2) and 0.91 (SD 0.2) for the pre and post-operative administered group of patients respectively (p<0.0001). No other intra-operative differences could be noted.
Emergence and recovery was rapid and no difference was noticed in time to discharge-eligible mean 52 minutes in both groups studied, one and five out of the 22 patients in the pre- and post operative group respectively need of analgesics during the stay in the recovery unit.
Conclusion: Adding a Coxib as pre-treatment during elective day surgery has anaesthetic sparing potentials.
Author: Ibrahim Turan, Anette Hein, Eva Jacobson and Jan G Jakobsson
Credits/Source: Journal of Orthopaedic Surgery and Research 2008, 3:40
Published on: 2008-09-11
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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