Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients
Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic CRC and HNPCC patients.
Methods: We analyzed a cohort of 40 (25 females and 15 males) HNPCC cases with a hospital series comprising 573 (312 and 261 respectively) sporadic CRC observed during the period 1970-1993. In fifteen HNPCC patients we performed mutational analysis for microsatellite instability.
Survival rates were calculated by Kaplan-Meier method and compared with log rank test.
Results: The mean age at diagnosis of the primary CRC was 46.8 years in the HNPCC series versus 61 years in sporadic CRC group.
In HNPCC group 85% had a right cancer location, vs. 57% in the sporadic cancer group.
In the sporadic cancer group 61.6% were early-stages cancer (Dukes' A and B) vs. 70% in the HNPCC group (p= ns).
The crude 5-years cumulative survival after the primary CRC was 94.2% in HNPCC patients vs. 75.3% in sporadic cancer patients (p<0.0001).
Conclusions: Our results show that overall survival of colorectal cancer in patients with HNPCC is better than sporadic CRC patients. The different outcome probably relates to the specific tumorigenesis involving DNA mismatch repair dysfunction.
Author: Vittoria Stigliano, Daniela Assisi, Maurizio Cosimelli, Raffaele Palmirotta, Diana Giannarelli, Marcella Mottolese, Lupe Sanchez Mete, Raffaello Mancini and Vincenzo Casale
Credits/Source: Journal of Experimental &Clinical Cancer Research 2008,
Published on: 2008-09-19
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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