Nuclear hBD-1 accumulation in malignant salivary gland tumours
Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue.
Methods: 21 paraffin-embedded tissue samples of benign (n=7), and malignant (n=7) salivary gland tumours as well as healthy (n=7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3.
Results: hBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.
Conclusions: HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours.
As HBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In Pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.
Author: M Wenghoefer, A Pantelis, H Dommisch, W Goetz, R Reich, M Martini, Jp Allam, S Jepsen, S Merkelbach-Bruse, Hp Fischer, S Berge, N Novak and J Winter
Credits/Source: BMC Cancer 2008, 8:290
Published on: 2008-10-07
Limited copyright is granted for you to use and/or republish any story on this site for
any legitimate media purpose as long as you reference 7thSpace and any source mentioned in the story above. Please
make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.
Social Bookmarking
Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
|
|
