Genetic characterization of Measles Viruses in China, 2004
Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1.
51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively.
The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.
Author: Yan Zhang, Yixin Ji, Xiaohong Jiang, Songtao Xu, Zhen Zhu, Lei Zheng, Jilan He, Hua Ling, Yan Wang, Yang Liu, Wen Du, Xuelei Yang, Naiying Mao and Wenbo Xu
Credits/Source: Virology Journal 2008, 5:120
Published on: 2008-10-20
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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