The tree of genomes: An empirical comparison of genome phylogeny reconstruction methods.

In the past decade or more, the emphasis for reconstructing species phylogenies has moved from the analysis of a single gene to the analysis of multiple genes and even completed genomes. The simplest method of scaling up is to use familiar analysis methods on a larger scale and this is the most popular approach.

However, duplications and losses of genes along with horizontal gene transfer (HGT) can lead to a situation where there is only an indirect relationship between gene and genome phylogenies. In this study we examine five widely-used approaches and their variants to see if indeed they are more-or-less saying the same thing.

In particular, we focus on Conditioned Reconstruction as it is a method that is designed to work well even if HGT is present.

Results: We confirm a previous suggestion that this method has a systematic bias.

We show that no two methods produce the same results and most current methods of inferring genome phylogenies produce results that are significantly different to other methods.

Conclusions: We conclude that genome phylogenies need to be interpreted differently, depending on the method used to construct them.

Author: Angela McCann, James A. Cotton and James O. McInerney
Credits/Source: BMC Evolutionary Biology 2008, 8:312

Published on: 2008-11-12

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