Aqueous fish extract increases survival in the mouse model of acute cytostatic toxicity
Treatment of cancer patients with anthracycline antibiotic doxorubicin (DOX) may be complicated by development of acute and chronic congestive heart failure (CHF), malignant arrhythmias and death. The aim of this study was to test whether an aqueous low molecular weight (LMW) extract from cod muscle decreases acute mortality in the mouse model of acute CHF caused by DOX.
Methods: A LMW fraction (<500 Da) of the aqueous phase of cod light muscle (AOX) was used for treatment of male BALB/c mice (~ 25 g, n = 70). The animals were divided into four groups, DOX + AOX (n = 20), DOX + saline (NaCl) (n = 30), NaCl + AOX (n = 10) and NaCl only (n = 10).
Echocardiography was performed in the separate subgroups (DOX treated n = 6 and controls n = 6) to verify the presence and the grade of acute CHF. The cod extract was delivered by subcutaneously implanted osmotic minipumps over the period of 2 weeks.
High-dose injection of DOX was administered to randomly selected animals. The animals received single intraperitoneal injection of DOX (25 mg/kg) and were followed over two weeks for mortality.
Results: Mortality rate was 67% lower (p <0.05) in the mice treated with the extract. The analyses of cod extract have shown strong antioxidative effect in vitro.
Conclusion: The aqueous LMW cod muscles extract decreases mortality in the mouse model of DOX induced acute CHF. This effect may be mediated by cardioprotection through antioxidative mechanisms.
Author: Elmir Omerovic, Malin Lindbom, Truls Ramunddal, Ann Lindgard, Ingrid Undeland, Ann-Sofie Sandberg and Bassam Soussi
Credits/Source: Journal of Experimental &Clinical Cancer Research 2008, 27:81
Published on: 2008-12-04
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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