Fatness and fitness: how do they influence health-related quality of life in type 2 diabetes mellitus?
ObjectiveWe examined whether adiposity and fitness explain the decrease in health-related quality of life (HRQOL) associated with type 2 diabetes mellitus (type 2 diabetes).
Methods: This was a cross-sectional study using baseline data from two exercise training interventions.
One study enrolled people with and the other without type 2 diabetes. We assessed aerobic fitness ("fitness") as peak oxygen uptake during treadmill testing, adiposity ("fatness") as percentage of total body fat by dual-energy x-ray absorptiometry, and HRQOL by the Medical Outcomes Study SF-36.
Bivariate and multivariate linear regression analyses were used to examine determinants of HRQOL.
Results: There were 98 participants with and 119 participants without type 2 diabetes.
Participants with type 2 diabetes had a mean hemoglobin A1c of 6.6% and, compared with participants without diabetes had lower HRQOL on the physical component summary score (P= 0.004), role-physical (P= 0.035), vitality (P= 0.062) and general health (P<0.001) scales after adjusting for age, sex and race. These associations of HRQOL with type 2 diabetes were attenuated by higher fitness, even more than reduced fatness.
Only general health remained positively associated with type 2 diabetes after accounting for fatness or fitness (P=0.003). There were no significant differences between participants with and without diabetes in the mental component score.
Conclusions: Improved fitness, even more than reducedfatness, attenuated the association of type 2 diabetes with HRQOL.
The potential to improve HRQOL may motivate patients with type 2 diabetes to engage in physical activity aimed at increasing fitness. Findings from this cross-sectional analysis will be addressed in the ongoing trial of exercise training in this cohort of participants with type 2 diabetes.
Trial registration: NCT00212303
Author: Wendy L Bennett, Pamela Ouyang, Albert W Wu, Bethany B Barone and Kerry J Stewart
Credits/Source: Health and Quality of Life Outcomes 2008, 6:110
Published on: 2008-12-04
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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