Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report

Obsessive-compulsive disorder is associated with a relevant impairment in social and interpersonal functioning and severe disability. This seems to be particularly true for the poor insight subtype, characterised by a lack of consciousness of illness and, consequently, compliance with treatment.

Poor responsiveness to serotonergic drugs in poor insight obsessive-compulsive patients may also require an augmentation therapy with atypical antipsychotics.

Methods: We reviewed a case in which a patient with a long history of poor insight obsessive-compulsive disorder was treated with a high dosage of serotonin reuptake inhibitors.

Results: The treatment resulted in a poor outcome. This patient was therefore augmentated with aripiprazole.

Conclusions: Doctors should consider aripiprazole as a possible augmentation strategy for serotonergic poor responder obsessive-compulsive patients, but further research on these subjects is needed.

Author: Michele Fornaro, Filippo Gabrielli, Chiara Mattei, Valentina Vinciguerra and Pantaleo Fornaro
Credits/Source: Annals of General Psychiatry 2008, 7:26

Published on: 2008-12-23

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