Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: a case report and review of literature
IntroductionChemotherapy Induced neutropenia is a frequent and serious complication of cytotoxic cancer treatment.Granulocyte colony stimulating factors (G-CSF) are frequently used to counter neutropenia, attempt rapid recovery of patients and allow for continuation of treatment without dose compromise, especially in curative malignancies. Generally regarded as safe, G-CSF use has been very rarely reported to have resulted in serious side effects, such as, splenic rupture.Case presentationWe are reporting a case of a twenty years old man, who was being treated for T cell acute lymphoblastic leukemia and received colony stimulating factors for treatment of severe neutropenia and suffered from splenic rupture, He was treated with splenectomy.
Conclusion: Although extremely rare, splenic rupture can be serious and sometimes life threatening complication of high dose colony stimulating factors therapy.
Author: Nehal Masood, Asim J Shaikh, Wasim A Memon and Romana Idress
Credits/Source: Cases Journal 2008, 1:418
Published on: 2008-12-24
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