Effect of sirolimus on urinary bladder cancer T24 cell line

Sirolimus is recently reported to have antitumour effects on a large variety of cancers. The present study was performed to investigate sirolimus's ability to inhibit growth in T24 bladder cancer cells.

Methods: T24 bladder cancer cells were treated with various concentrations of sirolimus.

MTT assay was used to evaluate the proliferation inhibitory effect on T24 cell line. The viability of T24 cell line was determined by Trypan blue exclusion analysis.

Results: Sirolimus inhibits the growth of bladder carcinoma cells and decreases their viability.

Significant correlations were found between cell proliferation and sirolimus concentration (r=0.830; p<0.01) as well as between cell viability and sirolimus concentration (r=-0.896; p<0.01).

Conclusion: Sirolimus has an anti-proliferation effect on the T24 bladder carcinoma cell line.

The information from our results is useful for a better understanding sirolimus's anti-proliferative activity in the T24 bladder cancer cell line.

Author: Rosario Pinto-Leite, Pedro Botelho, Eufemia Ribeiro, Paula A Oliveira and Lucio Santos
Credits/Source: Journal of Experimental &Clinical Cancer Research 2009, 28:3

Published on: 2009-01-07

Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.

Comments Page 0 of 0

There are currently 0 comments to display.

+ Add New Comment

Custom Search