Toll like receptor four (tlrfour) polymorphisms in Tunisian patients with crohn's disease: genotype-phenotype correlation

The immune responses to bacterial products through the pattern recognition receptor (PRR) play a pivotal role in pathogenesis of Crohn's disease. A recent study described an association between CD and some gene coding for bacterial receptor like NODtwo/CARD gene and TLRfour.

In this study, we sought to determine whether TLRfour gene was associated with Crohn's disease (CD) among the Tunisian population and its correlation with clinical manifestation of the disease.

Methods: nineteen patients with CD and eighteen healthy individuals are genotyped for the Asp/Gly and Thr/Ile polymorphisms by restriction fragment length polymorphism analysis.

Results: The allele and genotype frequency of the TLRfour polymorphisms did not differ between patients and controls. The genotype-phenotype correlation permitted to show that the Thr/Ile polymorphism was associated with early onset disease.

Conclusion: this study reported the absence of association between CD and TLRfour gene in the Tunisian population, but this gene could play a role in clinical expression of the disease.

Author: Lilia ZouitenMaher KharratSami KarouiMeriem SerghiniMonia FekihSamira MatriLamia KallelJalel BoubakerAzza FilaliHabiba Chaabouni
Credits/Source: BMC Gastroenterology 2009, 9:62

Published on: 2009-08-07

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