Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention
The objective was to investigate in a group of obese subjects the course in skeletal muscle phospholipid (SMPL) fatty acids (FA) during a 24-weeks weight maintenance program, which was preceded by a successful very low calorie dietary intervention (VLCD). Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action.
Methods: Nine obese subjects (BMI=35.7 +/- 1.0kg/m2), who had completed an 8 weeks VLCD (weight-loss=-9.7 +/- 1.6kg, P<0.001), had obtained skeletal muscle biopsies (vastus lateralis) before and after a dietician-guided 24-weeks weight-maintenance program (-1.2 +/- 1.5kg, P=ns).
SMPL FA composition was determined by gas liquid chromatography. During the preceding VLCD, insulin sensitivity (HOMA-IR) and glycemic control (HbA1c) improved but no change in SMPL omega-3 FA was observed.
During the weight-maintenance program five subjects received the pancreas lipase inhibitor Orlistat 120mg t.i.d. versus placebo.
Results: HOMA-IR and HbA1c stabilized and SMPL total omega-3 FA, docosahexaenoic acid and ratio of n-3/n-6 polyunsaturated FA increased by 24% (P<0.01), 35% (P<0.02) and 26% (P<0.01), respectively, whereas saturated and monounsaturated FA did not change.
Plasma total-cholesterol and LDL-cholesterol, which decreased during the VLCD, reverted to pre-VLCD levels (P<0.01). Orlistat therapy was associated with weight-loss (P<0.05), trends for better glycemic control (P=0.15) and greater increase in SMPL docosahexaenoic acid (P=0.12) but similar reversal of plasma cholesterols compared to placebo.
Conclusions: The data are consistent with the notion that greater SMPL omega-3 FA obtained during a weight-maintenance program may play a role for preserving insulin sensitivity and glycemic control being generated during a preceding VLCD.
Author: Steen HaugaardAllan VaagHuiling MuSten Madsbad
Credits/Source: Lipids in Health and Disease 2009, 8:34
Published on: 2009-08-13
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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