Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task

The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0 and 10 mg/kg) in the testing day.

Alpha-1 adrenergic receptor antagonist prazosin and alpha-2 adrenergic receptor antagonist RX821002 were used to clarify the RBX effect. Results revealed that rat received RBX at 10mg/kg had an increase in the percentage of the correct response and decreases in the numbers of premature response.

Alpha-1 adrenergic receptor antagonist prazosin at 0.1mg/kg reversed the RBX augmented correct responding rate. However, alpha-2 adrenergic receptor antagonist RX821002 at 0.05 and 0.1 mg/kg dose dependently reversed the RBX reduced impulsive responding.

Our results suggested that RBX as a norepinephrine transporter inhibitor can be beneficial in both attentional accuracy and response control and alpha-1 and alpha-2 adrenergic receptors might be involved differently.

Author: Yia-Ping LiuYu-Lung LinChia-Hsin ChuangYu-Cheng KaoShang-Tang ChangChe-Se Tung
Credits/Source: Journal of Biomedical Science 2009, 16:72

Published on: 2009-08-14

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