Pharmacologic attenuation of pelvic pain in a Murine model of interstitial cystitis
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a bladder disease that causes debilitating pelvic pain of unknown origin, and IC/PBS symptoms correlate with elevated bladder lamina propria mast cell counts. Similar to IC/PBS patients, pseudorabies virus (PRV) infection in mice induces a neurogenic cystitis associated with bladder lamina propria mast cell accumulation and pelvic pain.
We evaluated several drugs to determine the effectiveness of reducing PRV-induced pelvic pain.
Methods: Neurogenic cystitis was induced by the injection of Bartha's strain of PRVinto the abductor caudalis dorsalis tail base muscle of female C57BL/6 mice. Therapeutic modulation of pelvic pain was assessed daily for five days using von Frey filament stimulation to the pelvic region to quantify tactile allodynia.
Results: Significant reduction of PRV-induced pelvic pain was observed for animals treated with antagonists of neurokinin receptor 1 and histamine receptors.
In contrast, the H1R antagonist hydroxyzine, proton pump inhibitors, a histamine receptor 3 agonist, and gabapentin had little or no effect on PRV-induced pelvic pain.
Conclusions: These data demonstrate that bladder-associated pelvic pain is attenuated by antagonists of NK1R, H2R, and H1R. Therefore, NK1R, H2R and H1R represent direct therapeutic targets for pain in IC/PBS and potentially other chronic pain conditions.
Author: Charles RudickAnthony SchaefferDavid Klumpp
Credits/Source: BMC Urology 2009, 9:16
Published on: 2009-11-12
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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