Acitretin-associated erectile dysfunction: a case report

Introduction Two cases of impotence following a treatment with etretinate have been reported in the literature. Acitretin is the principal active metabolite of etretinate.

We report a case of erectile dysfunction associated with the use of acitretin.Case presentation A 39-year-old Caucasian man referred his incapacity to reach and maintain a penile erection during a course of acitretin for the treatment of a severe form of psoriasis. Physical examination, laboratory findings and psychological analysis did not reveal any abnormalities.

Two weeks after the withdrawal of acitretin, the patient reported a normalization of his sexual activity.Conclusions Retinoids have been associated with male reproductive system dysfunctions in human and animal studies. Clinicians should be aware of the possibility of acitretin-induced erectile dysfunction.

Author: Marco RossiMichele Pellegrino
Credits/Source: Cases Journal 2009, 2:210

Published on: 2009-11-19

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