Specific subsets of immune cells in human decidua differ between normal pregnancy and preeclampsia - a prospective observational study
Changes in the balance of decidual leucocyte populations may lead to an unfavourable uterine microenvironment which may be associated with the development of preeclampsia (PE). In this study, we therefore investigated the leucocyte subpopulations in decidual tissues of 33 women with preeclampsia and 66 control patients.
Methods: Decidua was either obtained via curettage during cesarean section or dissected from the surface of the basal plate of the placenta after spontaneous delivery.
We used FACS analysis to quantify decidual leukocytes (CD45), NK cells (CD56+/CD16+ and CD56++/CD16-), antigen presenting cells (HLA-DR, DC-Sign, CD14) and T/B cells (CD8, CD4, alpha-beta-T-cell receptor, gamma-delta-T-cell receptor, CD25, CD19).
Results: The number of decidual cytotoxic CD8+T-lymphocytes (P<0.02), alpha-beta -T-cell receptor positive T cells (P<0.03) and of CD56+/CD16+ NK cells (P<0.03) was lower in decidua from women with PE than in decidua from controlpatients.
Conclusion: The observed reduction of specific leucocyte subsets could create a microenvironment which is unfavourable for an appropriate placentation and could thereby be involved in the development of preeclamptic symptoms.
Author: Lorenz RiegerSabine SegererThomas BernarMichaela KappMonika MajicAnn-Katrin MorrJohannes DietlUlrike Kammerer
Credits/Source: Reproductive Biology and Endocrinology 2009, 7:132
Published on: 2009-11-23
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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