The expression and significance of P-glycoprotein, lung resistnce protein and multidrug resistance-associated protein in gastric cancer
To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and the clinico-pathological features.
Methods: The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin -Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data. None of these patients received chemotherapy prior to surgery.
Results: The positive rates of P-gp, LRP, MRP were 86.4%, 84.7% and 27.1%, respectively.
The difference between the positive rate of P-gp and MRP was significant statistically, as well as the difference between the expression of MRP and LRP. No significant difference was observed between P-gp and LRP, but the positively correlation between the expression of P-gp and LRP had been found.
No significant correlation between the expression of P-gp, LRP, MRP and the grade of differentiation were observed. The expression of P-gp was correlated with clinical stages positively (r=0.742), but the difference with the expression of P-gp in different stages was not significant.
Conclusion: The expressions of P-gp, LRP and MRP in patients with gastric cancer without prior chemotherapy are high, indicating that innate drug resistance may exist in gastric cancer.
Author: Wen-Qing HuChen-Wei PengYan Li
Credits/Source: Journal of Experimental &Clinical Cancer Research 2009, 28:144
Published on: 2009-11-24
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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