Calciphylaxis following kidney transplantation: a case report

IntroductionCalciphylaxis occurring after kidney transplantation is rare and rarely reported. It results in chronic non-healing wounds and is associated with a poor prognosis and is often fatal.

We present a case of proximal lower limb calciphylaxis that occurred early after kidney transplantation. The patient had no classic associated risk factors.

He had previously had a total parathyroidectomy and had a normal serum calcium-phosphate product and parathyroid hormone levels. The clinical outcome of this case was favorable and highlights some fundamental issues relating to management.Case presentationA 70-year-old British Caucasoid male with end-stage renal failure secondary to IgA nephropathy presented six months post kidney transplantation with cutaneous calciphylaxis lesions involving the medial aspect of the thigh bilaterally.

Conclusion: To the best of our knowledge, this is the first reported case of rapid onset cutaneous calciphylaxis occurring soon after kidney transplantation that was associated with a favorable outcome.

Cutaneous calciphylaxis lesions should be promptly managed with meticulous wound care, antimicrobial therapy and the correction of calcium-phosphate product where indicated.

Author: Rajesh HanvesakulMichael SilvaRahul HejmadiSteve MellorAndrew ReadyPaul CockwellNicholas Inston
Credits/Source: Journal of Medical Case Reports 2009, 3:9297

Published on: 2009-11-24

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