Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium

Different molecular alterations have been described in endometrioid endometrial carcinoma (EECA). Among them the most frequently altered is loss of the PTEN protein, a tumor suppressor gene.

The purpose of this study was to evaluate the expression pattern of PTEN gene in normal, hyperplastic and neoplastic endometrium.

Methods: In a prospective study in a referral gynecologic hospital in Tehran, Iran,immunohistochemical (IHC) evaluation of PTEN was performed on 87 consecutivespecimens to the following three groups; group A- normal proliferative endometrium(n=29); group B- hyperplastic endometrium [including simple hyperplasia without atypia(n=21) and complex hyperplasia with atypia (n=8)] and group C- EECA(n=29). Immunostaining of cells was analyzed by arbitrary quantitative methods according to both slide's area staining and intensity of color reaction.

Results: PTEN immunoreactivity was present in all normal proliferative endometrium, all simple hyperplasia, 75% of atypical complex hyperplasia and in 48% of EECA (P<0.001).

The intensity of PTEN reaction was significantly higher in group with proliferative endometrium than hyperplastic endometrium and EECA (P<0.001).

Conclusions: PTEN expression was significantly higher in cyclical endometrium than in atypical hyperplasia and endometrioid carcinoma.

Author: Soheila SarmadiNarges Izadi-MoodKambiz SotoudehSeyed Mohammad Tavangar
Credits/Source: Diagnostic Pathology 2009, 4:41

Published on: 2009-11-25

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