Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations.
This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women.FindingsParticipants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 women controls (101 black African and 323 women of mixed-ancestry), matched by age and domicile (urban or rural). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844C/T) were genotyped by TaqMan.
None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group.
However, on analysis ofthe control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry.
Conclusions: This is the first study of the role of Fas and FasL polymorphisms in cervical cancer in African populations.
Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations.
Author: Koushik ChatterjeeMalin EngelmarkUlf GyllenstenCollet DandaraLize van der MerweUshma GalalMargaret HoffmanAnna-Lise Williamson
Credits/Source: BMC Research Notes 2009, 2:238
Published on: 2009-11-26
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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