Jellyfish mucin may have potential disease modifying effects of osteoarthritis
We aimed to study the effects of the intra-articular injection of jellyfish mucin (qniumucin) on articular cartilage degeneration in a model of osteoarthritis (OA) created in rabbit knees by the resection of the anterior cruciate ligament.Qniumucin was extracted from Aurelia aurita (moon jellyfish) and Stomolophus nomurai (Nomura's jellyfish) and purified by ion exchange chromatography. The OA model used 36 knees in 18 Japanese white rabbits.
Purified qniumucin extracts from S. nomurai or A.
aurita were used at 1 mg/ml. The rabbits were divided into four groups: a control (C) group (injected with saline), a hyaluronic acid (HA) only group (H group), two qniumucin only groups (M groups) and two qniumucin + HA groups (MH groups).
One milligram of each solution was injected intra-articularly once a week for five consecutive weeks, starting from four weeks after surgery. Ten weeks after surgery, the articular cartilage was evaluated macroscopically and histologically.
Results: In the C and M groups, macroscopic cartilage defects extended to the subchondral bone on the medial and lateral sides.
When the H and both MH groups were compared, only minor cartilage degeneration was observed in the groups treated with qniumucin in contrast to the group without qniumucin. Histologically, densely safranin-O-stained cartilage layers were observed in the H and two MH groups, and furthermore the cartilage was strongly maintained in both MH groups.
Conclusion: At the concentrations of qniumucin used in this study, its injection together with HA inhibited articular cartilage degeneration in this model of OA.
Author: Naoshi OhtaMasato SatoKiminori UshidaMami KokuboTakayuki BabaKayoko TaniguchiMakoto UraiKoji KihiraJoji Mochida
Credits/Source: BMC Biotechnology 2009, 9:98
Published on: 2009-12-09
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.
Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
|
|
Seo Service
Cheap Seo Service
Best Seo Service
Seo Service,
Cheap Seo Service,
Best Seo Service,