Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis
Hereditary hemochromatosis (HH) is an autosomal recessive disorder mainly associated with homozygosity for the C282Y and H63D mutations in the hemochromatosis (HFE) gene. To clarify the relationship between C282Y and H63D mutations and hepatocellular carninoma (HCC), a meta-analysis including nine studies (1102 HCC cases and 3766 controls) was performed.
Methods. The association was measured using random-effect (RE) or fixed-effect (FE) odds ratios (ORs) combined with 95% confidence intervals (CIs) according to the studies'heterogeneity.
Results. Meta-analysis of nine studies with all controls showed that Y allele of C282Y was associated with HCC risk: RE OR reached 1.50 (95%CI: 1.05-2.14, p for heterogeneity=0.02, I2=0.57).
However, the sensitivity analysis showed the result was not robust. Subgroup analysis of seven studies also showed Y allele was associated with HCC in healthy populations: RE OR reached 1.61 (95%CI: 1.08-2.39, p for heterogeneity=0.04, I2=0.55).
The sensitivity analysis also showed the result was not robust. We further did subgroup analysis and found that both the dominant model and Y allele of C282Y were associated with HCC risk in alcoholic liver cirrhosis (LC) patients (FE OR reached 4.06, 95%CI: 2.08-7.92 and 3.41, 95%CI: 1.81-6.41, respectively).
Overall, there was no distinct heterogeneity among the studies (I2=0). The subgroup analysis did not show association of C282Y with HCC among viral LC patients.
H63D mutation did not show evidence of the association with HCC. Conclusions.
C282Y mutation was associated with HCC in European alcoholic LC patients.
Author: Fei JinLi-Shuai QuXi-Zhong Shen
Credits/Source: Journal of Experimental &Clinical Cancer Research 2010, 29:18
Published on: 2010-03-02
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