Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally-sensitive protein complexes.

Co-inhibitory compounds were weakly correlated by structure and therapeutic class. We developed an algorithm predicting protein targets of chemical compounds and verified its accuracy with experimental testing.

Fitness data provide a novel, systems-level perspective on the cell.

Author: Maureen HillenmeyerElke EricsonRonald DavisCorey NislowDaphne KollerGuri Giaever
Credits/Source: Genome Biology 2010, 11:R30

Published on: 2010-03-12

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