Low prevalence of Human Papillomavirus in oral cavity carcinomas
Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported.
Methods: We assessed HPV involvement in HNSCC using the Roche Linear Array HPV Genotyping Test, which can detect 37 different HPV types. We examined the prevalence of HPV infection in 92 HNSCCs (oropharynx, oral cavity, and other HNSCC sites).
Results: HPV was frequently detected in oropharyngeal cancers (OPCs) (16/22, 73%), but was uncommon in oral cavity cancers (2/53, 4%), and in other HNSCC subsites (1/17, 6%).
HPV positive tumors were associated with patients that were 40-60 years old (p=0.02), and node positive (p=<0.0001). HPV 16 was the most prevalent type, but other types detected included 6, 18, 33, 35, 45, and 52/58.
Conclusion: Our results show that in contrast to oropharyngeal cancers, oral cancers and other HNSCCs infrequently harbor HPV.
Author: Jerry MachadoPatricia ReisTong ZhangColleen SimpsonWei XuBayardo Perez-OrdonezDavid GoldsteinDale BrownRalph GilbertPatrick GullaneJonathan IrishSuzanne Kamel-Reid
Credits/Source: Head &Neck Oncology 2010, 2:6
Published on: 2010-03-12
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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But I got HPV 6 months ago, my boyfriend left me. I had to date singles living with HPV on Positivefish.com =.
Thank god, I finally met someone!!