Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy

Background Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility.Objectives The aim of this study was to evaluate the development of neo-sensitization to Pen a 1 (tropomyosin) as well as the appearance of reactions after ingestion of foods containing tropomyosin as a consequence of sublingual mite immunization.Material and methods Specific IgE to Tropomyosin (rPen a 1) before and after mite sublingual immunotherapy in 134 subjects were measured. IgE-specific antibodies for mite extract and recombinant allergen Pen a 1 were evaluated using the immunoenzymatic CAP system (Phadia Diagnostics, Milan, Italy).Results All patients had rPen a 1 IgE negative results before and after mite SLIT and did not show positive shrimp extract skin reactivity and serological rPen a 1 IgE conversion after treatment.

More important, no patient showed systemic reactions to crustacean ingestion.Conclusions Patients did not show neo-sensitization to tropomyosin, a component of the extract (namely mite group 10) administered. An assessment of a patient's possible pre-existing sensitisation to tropomyosin by skin test and/or specific IgE prior to start mite extract immunotherapy is recommended.

Author: Renato RossiGiorgio MonasteroloCristoforo IncorvaiaPhilippe MoingeonFranco FratiGiovanni PassalacquaLucilla RossiGiorgio Canonica
Credits/Source: Clinical and Molecular Allergy 2010, 8:4

Published on: 2010-03-15

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