Library of molecular associations: curating the complex molecular basis of liver diseases
Systems biology approaches offer novel insights into the development of chronic liver diseases. Current genomic databases supporting systems biology analyses are mostly based on microarray data.
Although these data often cover genome wide expression, the validity of single microarray experiments remains questionable. However, for systems biology approaches addressing the interactions of molecular networks comprehensive but also highly validated data are necessary.
Results: We have therefore generated the first comprehensive database for published molecular associations in human liver diseases.
It is based on PubMed published abstracts and aimed to close the gap between genome wide coverage of low validity from microarray data and individual highly validated data from PubMed. After an initial text mining process, the extracted abstracts were all manually validated to confirm content and potential genetic associations and may therefore be highly trusted.
All data were stored in a publicly available database, Library of Molecular Associations (http://www.medicalgenomics.org/databases/loma/news), currently holding approximately 1260 confirmed molecular associations for chronic liver diseases such as HCC, CCC, liver fibrosis, NASH/fatty liver disease, AIH, PBC, and PSC. We furthermore transformed these data into a powerful resource for molecular liver research by connecting them to multiple biomedical information resources.
Conclusion: Together, this database is the first available database providing a comprehensive view and analysis options for published molecular associations on multiple liver diseases.
Author: Stefan BuchkremerJasmin HendelMarkus KruppArndt WeinmannKai SchlampThorsten MaassFrank StaibPeter GalleAndreas Teufel
Credits/Source: BMC Genomics 2010, 11:189
Published on: 2010-03-21
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.
Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
|
|
