Controlling Hypertension Immediately Post Stroke - a cost utility analysis of a pilot randomised controlled trial

Elevated blood pressure (BP) levels are common following acute stroke. However, there is considerable uncertainty if and when antihypertensive therapy should be initiated.MethodEconomic evaluation alongside a double-blind randomised placebo-controlled trial (National Research Register Trial Number N0484128008) of 112 hypertensive patients receiving an antihypertensive regimen (labetalol or lisinopril) within 36 hours post stroke versus 59 receiving placebo.

Outcomes were incremental cost per incremental: QALY, survivor, and patient free from death or severe disability (modified Rankin scale score <4) at three months and 14 days post stroke.

Results: Actively treated patients on average had superior outcomes and lower costs than controls at three months. From the perspective of the acute hospital setting, there was a 96.5% probability that the incremental cost per QALY gained at three months is below GBP30,000, although the probability may be overstated due to data limitations.

Conclusion: Antihypertensive therapy when indicated immediately post stroke may be cost-effective compared with placebo from the acute hospital perspective.

Further research is required to confirm both efficacy and cost-effectiveness and establish whether benefits are maintained over a longer time horizon.

Author: Edward WilsonGary FordTom RobinsonAmit MistriCarol JaggerJohn Potter
Credits/Source: Cost Effectiveness and Resource Allocation 2010, 8:3

Published on: 2010-03-23

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