Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial

IntroductionAntibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments.Aims&methods: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxacin with lansoprasole and amoxycillin according to moxifloxacin resistance.

Patients with non-ulcer dyspepsia and culture and histology positive Hp infection (n=150) were randomly assigned into two groups. The first group (n=75) received moxifloxacin 400 mg/d during 7 days and the other (n=75) received moxifloxacin 400 mg/d during 10 days.

All patients received amoxycillin 1 g twice daily, lansoprasole 30 mg twice daily. All Hp cultures were tested for sensitivity to moxifloxacin.

Results: 138 patients (92%) completed the study, 68 in the first group and 70 in the second.

Eradication rates were 84% (57/68) and 76% (57/75) in the 7 days moxifloxacin group and 90% and 84% in the second group (63/70, 63/75) according to the PP and ITT analysis; p=n.s. Among 129 patients (86% of study group), 6% of strains were primary resistant to moxifloxacin.Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p<0.05

Conclusion: According to our results we recommend 7 days moxiflixacin based triple therapy.

Author: Josip BagoKarolina MajstorovicZeljka Belosic-HalleNastja KucisecVinko BakulaMonika TomicPetra BagoRosana Troskot
Credits/Source: Annals of Clinical Microbiology and Antimicrobials 2010, 9:13

Published on: 2010-04-15

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