Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension


Liver dysfunction reflects the status of heart failure, with congestion and low perfusion of the liver serving as causative mechanisms. Previous studies demonstrated relationship between the results of liver function test and the prognosis in patients with heart failure.

However, few studies have examined this relationship in patients with pulmonary arterial hypertension (PAH).

Methods: The subjects were 37 patients with PAH (8 men and 29 women; 18 with idiopathic PAH and 19 with connective tissue disease-associated PAH). A blood test was performed after a 3-month period free from hospitalization and without changes in functional class, treatment, heart sounds, body weight, or heart rate.

Results: In a mean follow-up period of 635 +/- 510 days, 12 patients died due to heart failure, 2 died due to pulmonary hemorrhage, and 23 patients survived.

Cox proportional hazard analyses identified functional class (p <0.001), plasma concentration of brain natriuretic peptide (BNP) (p = 0.001), and hyperbilirubinemia (serum total bilirubin >1.2 mg/dL; p <0.001; hazard ratio = 13.31) as predictors of mortality. Patients with hyperbilirubinemia had a worse functional class (P = 0.003), a higher right atrial pressure (p <0.001), a higher plasma concentration of BNP (p = 0.004), and a larger Doppler right ventricular index (p = 0.041).

Conclusion: Elevated serum bilirubin is a risk factor for death in patients with PAH.

Author: Yasuko TakedaYutaka TakedaShigehiro TomimotoTomomitsu TaniHitomi NaritaGenjiro Kimura
Credits/Source: BMC Pulmonary Medicine 2010, 10:22



Published on: 2010-04-22



News Provider: 7thSpace Interactive

Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.

Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo



Comments

There are no comments available. Be the first to write a comment.


You need to enable Javascript to post a comment.


Custom Search

Username
Password










© 2014 7thSpace Interactive
All Rights Reserved - About | Disclaimer | Helpdesk
There are currently 24661 people browsing 7thSpace (S2)