Can concurrent core biopsy and fine needle aspiration biopsy improve the false negative rate of sonographically detectable breast lesions?
The aims of this study were to determine the accuracy of concurrent core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB) for breast lesions and to estimate the false-negative rate using the two methods combined.
Methods: Over a seven-year period, 2053 patients with sonographically detectable breast lesions underwent concurrent ultrasound-guided CNB and FNAB. The sonographic and histopathological findings were classified into four categories: benign, indeterminate, suspicious, and malignant.
The histopathological findings were compared with the definitive excision pathology results. Patients with benign core biopsies underwent a detailed review to determine the false-negative rate.
The correlations between the ultrasonography, FNAB, and CNB were determined.
Results: Eight hundred eighty patients were diagnosed with malignant disease, and of these, 23 (2.5%) diagnoses were found to be false-negative after core biopsy. After an intensive review of discordant FNAB results, the final false-negative rate was reduced to 1.1% (p-value = 0.025).
The kappa coefficients for correlations between methods were 0.304 (p-value <0.0001) for ultrasound and FNAB, 0.254 (p-value <0.0001) for ultrasound and CNB, and 0.726 (p-value <0.0001) for FNAB and CNB.
Conclusions: Concurrent CNB and FNAB under ultrasound guidance can provide accurate preoperative diagnosis of breast lesions and provide important information for appropriate treatment. Identification of discordant results using careful radiological-histopathological correlation can reduce the false-negative rate.
Author: Yao-Lung KuoTsai-Wang Chang
Credits/Source: BMC Cancer 2010, 10:371
Published on: 2010-07-16
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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