Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy
Backgroud: To define the clinical target volume (CTV) for radiotherapy in patients with hepatocellular carcinoma (HCC).
Methods: A prospective study was conducted to histologically evaluate the presence and the distance of microscopic extension (ME) for resected HCC on the basis of examination of whole-mount preparations of carcinoma tissue sections.
Results: A total of 380 whole-mount slides prepared from tumor samples of 76 patients with HCC were examined. Patients with elevated pretreatment AFP levels exhibited higher risk of ME as compared to those with normal pretreatment AFP levels (93.9% vs.
69.8%, P<0.01). ME positivity was 16.7% for Grade 1, 79.1% for Grade 2, and 96.3% for Grade 3 tumors (P<0.01).
The mean distance of ME was 0.0+/-0.1 mm ( range 0-0.2 mm) for Grade 1, 0.9+/-0.9 mm (range 0-4.5 mm) for Grade 2, and 1.9+/-1.9 mm (range 0-8.0 mm) for Grade 3 tumors (P<0.01).
Conclusions: The CTV margins for tumor Grades 1, 2, and 3 HCC, are recommended to be 0.2 mm, 4.5 mm, and 8.0 mm beyond the gross tumor margin, respectively, to account for possible ME of the tumors in all patients.
Author: Weihu WangXiaoli FengTao ZhangJing JinShulian WangYueping LiuYongwen SongXinfan LiuZihao YuYexiong Li
Credits/Source: Radiation Oncology 2010, 5:73
Published on: 2010-08-23
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.
Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
|
|
