Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model

Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension.

In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model.

Methods: In male Sprague-Dawley rats, pulmonary hypertension was induced by subcutaneous administration of monocrotaline at a concentration of 6 mg/100 g body weight. Hydrogen-rich saline (5 ml/kg) or saline was administred intraperitoneally once daily for 2 or 3 weeks.

Severity of pulmonary hypertension was assessed by hemodynamic index and histologic analysis. Malondialdehyde and 8-hydroxy-desoxyguanosine levels, and superoxide dismutase activity were measured in the lung tissue and serum.

Levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in serum were determined with enzyme-linked immunosorbent assay.

Results: Hydrogen-rich saline treatment improved hemodynamics and reverse right ventricular hypertrophy. It also decreased malondialdehyde and 8-hydroxy-desoxyguanosine levels, and increased superoxide dismutase activity in the lung tissue and serum, accompanied by a decrease in pro-inflammatory cytokines.

Conclusions: These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats, which may be associated with its antioxidant and anti-inflammatory effects.

Author: Yun WangLei JingXiao-Min ZhaoJi-Ju HanZuo-Li XiaShu-Cun QinYa-Ping WuXue-Jun Sun
Credits/Source: Respiratory Research 2011, 12:26

Published on: 2011-03-04

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