Magnetic Resonance Imaging for Lung Cancer Detection: Experience in a Population of More Than 10,000 Healthy Individuals
Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of primary lung cancer in asymptomatic individuals.
Methods:
A retrospective chart review was performed on images of lung parenchyma, which were extracted from whole-body MRI examinations between October 2000 and December 2007.
11,766 consecutive healthy individuals (mean age, 50.4 years; 56.8% male) were scanned using one of two 1.5-T scanners (Sonata and Sonata Maestro, Siemens Medical Solutions, Erlangen, Germany). The standard protocol included a quick whole-lung survey with T2-weighted 2-dimensional half Fourier acquisition single shot turbo spin echo (HASTE) and 3-dimensional volumetric interpolated breath-hold examination (VIBE).
Total examination time was less than 10 minutes, and scanning time was only 5 minutes. Prompt referrals and follow-ups were arranged in cases of suspicious lung nodules.
Results:
A total of 559 individuals (4.8%) had suspicious lung nodules.
A total of 49 primary lung cancers were diagnosed in 46 individuals: 41 prevalence cancers and 8 incidence cancers. The overall detection rate of primary lung cancers was 0.4%.
For smokers aged 51 to 70 years, the detection rate was 1.4%. TNM stage I disease accounted for 37 (75.5%).
The mean size of detected lung cancers was 1.98 cm (median, 1.5 cm; range, 0.5-8.2 cm). The most histological types were adenocarcinoma in 38 (77.6%).
Conclusion:
Rapid zero-dose MRI can be used for lung cancer detection in a healthy population.
Author: Nai-Yuan WuHui-Cheng ChengJames KoYu-Chen ChengPo-Wei LinWei-Chan LinCheng-Yen ChangDer-Ming Liou
Credits/Source: BMC Cancer 2011, 11:242
Published on: 2011-06-13
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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