Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment.
Primary bone sarcomas affect children and young adults. Osteosarcoma and Ewing sarcoma are the most common histological subtypes in this age group, with current multimodality treatment strategies achieving 55-70% overall survival.
There remains an urgent need to develop new therapeutic interventions. Here we reviewed published phase I/II trials that have been reported for osteosarcoma and Ewing sarcoma.
Findings: We conducted a literature search for clinical trials between 1990 and 2010, either for trials enrolling bone sarcoma patients as part of a general sarcoma indication or trials specifically in osteosarcoma and Ewing sarcoma. We identified 42 trials for sarcoma that enrolled these patient groups, and eight and twenty specific trials for Ewing and osteosarcoma patients, respectively.
For phase I trials our results were incomplete, as sarcoma patients were often not mentioned in abstracts. A total of 3,736 patients were included in these trials, 1,114 and 1,263 for Osteosarcoma and Ewing sarcoma, respectively.
As a proportion of the worldwide disease burden over this period, these numbers reflect a very small percentage of the potential patient recruitment, approximately 0.6% for Ewing sarcoma and 0.2% for osteosarcoma.
Conclusion: International collaboration exists in co-operative groups for phase III trials, but progress may be imporved with investment of molecular and translational research into disease focused phase I/II clinical trials.
Examples of new models for early translational phase trial collaboration include the EuroBoNeT network, the Sarcoma Alliance for Research through Collaboration network (SARC) and the new European collaborative translational trial network, EuroSarc.
Author: Annemiek M Van MaldegemAparna BhosaleHans J GelderblomPancras CW HogendoornAndrew B Hassan
Credits/Source: Clinical Sarcoma Research 2012, 2:5
Published on: 2012-01-27
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please
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