Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever

Altered plasma concentrations of vitamin D and mannose binding lectin (MBL), componentsof innate immunity, have been shown to be associated with the pathogenesis of viralinfections. The objective of the present study was to find out whether plasma concentrationsof MBL and vitamin D are different in patients with dengue fever (DF) and denguehemorrhagic fever (DHF).The resultsThe plasma concentrations of vitamin D and MBL were assessed in 48 DF cases, 45 DHFcases and 20 apparently healthy controls using ELISA based methods.

Vitamin Dconcentrations were found to be higher among both DF and DHF cases as compared tohealthy controls (P <0.005 and P <0.001). Vitamin D concentrations were not differentbetween DF and DHF cases.

When the dengue cases were classified into primary andsecondary infections, secondary DHF cases had significantly higher concentrations ofvitamin D as compared to secondary DF cases (P <0.050). MBL concentrations were notsignificantly different between healthy controls and dengue cases.

MBL concentrations wereobserved to be lower in DHF cases as compared to DF cases (P <0.050). Although MBLlevels were not different DF and DHF cases based on immune status, the percentage ofprimary DHF cases (50%) having MBL levels lower than 500 ng/ml were less compared toprimary DF cases (P = 0.038).

Conclusions: The present study suggests that higher concentrations of vitamin D might be associated withsecondary DHF while deficiency of MBL may be associated with primary DHF.

Author: Kalichamy AlagarasuRupali V BachalAsha B BhagatParesh S ShahCecilia Dayaraj
Credits/Source: Virology Journal 2012, 9:86

Published on: 2012-05-04

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