Does duration of untreated psychosis predict very long term outcome of schizophrenic disorders? results of a retrospective study

Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. follow-ups of ten years or more) are somewhat limited.

The aim of this study was to evaluate the potential association between DUP and very long-term outcome (approx. 25 yrs) of schizophrenia by means of a retrospective design.

Methods: retrospective data obtained from clinical records for a cohort of 80 outpatients (52 Males, 28 Females, mean age 51+/- 11.58 years) affected by schizophrenia according to DSMIVTR attending a university community mental health centre took part in the study.

Results: Mean duration of follow up was 25.2 +/- 8.68 years; Mean duration of untreated psychosis was 49.00+/-78.86 months, with no significant difference according to gender.

Patients with a shorter DUP (=/
Conclusion: a shorter DUP appears to act as a significant predictor of better outcome in schizophrenia even in the very long-term.

Author: diego primaverachiara bandecchitiziana leporilucia sannaeraldo nicotrabernardo carpiniello
Credits/Source: Annals of General Psychiatry 2012, 11:21

Published on: 2012-08-03

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