Treatment-independent miRNA signature in blood of wilms tumor patients

Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared themiRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOPprotocol 2001.

Results: We did not find a significant difference between miRNA signature of both groups.

However both, Wilmstumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. Thesignature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients afterchemotherapy an accuracy of 97.0%, each as compared to healthy controls.

Conclusion: Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of fourweeks preoperative chemotherapy treatment.

Author: Jana SchmittChristina BackesNasenien Nourkami-TutdibiPetra LeidingerStephanie DeutscherMarkus BeierManfred GesslerNorbert GrafHans-Peter LenhofAndreas KellerEckart Meese
Credits/Source: BMC Genomics 2012, 13:379

Published on: 2012-08-07

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