Relationship between blood lipid profiles and pancreatic islet ß cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study
Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). The purpose of this study was to investigate the relationship between lipid profiles and beta cell function in Chinese individuals with NGT but without history of diabetes or prediabetes.
Methods:
A total of 893 men and 1454 women aged 18--76 years living in Sichuan, China, who were not being treated with lipid-lowering drugs were enrolled in this study.
Insulin sensitivity (IR) was evaluated using the homeostasis model assessment --IR (HOMA-IR), beta-cell function was calculated by the following equation: DeltaI30/DeltaG30/ HOMA-IR (DeltaI30/DeltaG30: the ratio of incremental glucose and insulin 30 min after glucose intake). Multivariate linear regression analyses were performed to estimate the relationship between blood lipid and beta cell function as standardized coefficients (beta).
Results:
beta cell function decreased in men and women with increasing age.
We found inverse relationships between beta cell function and total cholesterol (TC) in men and women (beta = [MINUS SIGN]0.157 and [MINUS SIGN]0.113, respectively, both p <0.001), low-density lipoprotein--cholesterol (LDL-C; beta = [MINUS SIGN]0.130 and [MINUS SIGN]0.068, respectively, both p <0.001), TC/high-density lipoprotein--cholesterol (HDL-C) ratio (beta = [MINUS SIGN]0.084, p <0.01 and [MINUS SIGN]0.096, p <0.001), and triglycerides (TG) (women only; beta = [MINUS SIGN]0.053, p <0.05). However, beta cell function was not associated with HDL-C in men or women (beta = [MINUS SIGN]0.034 and 0.000, respectively, both p >0.05) or the TG/HDL-C ratio (beta = [MINUS SIGN]0.035 and [MINUS SIGN]0.013, respectively, both p >0.05).
beta cell function was significantly worse in males than in females in all age groups, except in subjects aged >70 years.
Conclusions:
Dyslipidemia is associated with dysfunction of pancreatic beta cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males.Trial Registration Number#TR-CCH-Chi CTR-CCH-00000361
Author: tianpeng Zhengyun Gaohaoming Tian Credits/Source: BMC Public Health 2012, 12:634
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