Testing of human papillomavirus in lung cancer and non-tumor lung tissue
Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear.
We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA in both lung tumor specimens and adjacent non-tumoral specimens from the same patients. Thirty-five of the most clinically relevant HPV types were assayed using PCR amplification of the highly conserved L1 region of the viral genome followed by hybridization with specific probes.
No HPV was detected in tumor specimens nor in normal lung tissue of any patient.
These data indicate that, in this Western series, HPV is not associated with the risk of lung cancer.
Our findings will help refine estimates of lung cancer risk in patients affected by a common viral infection involved in other types of human cancer.
Author: Antonella GalvanSara NociFrancesca TavernaClaudia LombardoSilvia FranceschiUgo PastorinoTommaso A Dragani
Credits/Source: BMC Cancer 2012, 12:512
Published on: 2012-11-13
Copyright by the authors listed above - made available via BioMedCentral
(Open Access). Please
make sure to read our disclaimer
prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk
. If you wish submit your own press release, click here